• deplazio
    The Department of Epidemiology of the Lazio Regional Health Service (DEP)
    is based in Rome and has over 30 years of experience
  • Area Covid-19
  • ambientale-valutativo

    The staff of the DEP has specific expertise in epidemiological methods
  • rischi ambientali
    Provide decision makers with the best epidemiological evidence
    to plan interventions to reduce health risks
  • esiti
    Outcome evaluation of health care
  • cure sanitarie
    Provide evidence to improve the quality
    and effectiveness of health care
  • inquinamento
    Assess the risks associated with
    short and long term exposure to air pollutants
  • cambiamenti climatici
    Assessing the health impact of climate change and extreme events

Registro Regionale Dialisi e Trapianti Lazio (RRDTL)


Sunaga T, Maeda M, Saulle R, Ng SM, Sato MT, Hasegawa T, Mason AN, Noma H, Ota E.

Anti-vascular endothelial growth factor biosimilars for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2024 Jun 3;6(6):CD015804. doi: 10.1002/14651858.CD015804.pub2. PMID: 38829176; PMCID: PMC11146280.

Servadio M, Rosa AC, Addis A, Kirchmayer U, Cozzi I, Michelozzi P, Cipelli R, Heiman F, Davoli M, Belleudi V. 

Investigating socioeconomic disparities in lung cancer diagnosis, treatment and mortality: an Italian cohort study. BMC Public Health. 2024 Jun 7;24(1):1543. doi: 10.1186/s12889-024-19041-4. PMID: 38849792; PMCID: PMC11161996.

Kadelbach P, Weinmayr G, Chen J, Jaensch A, Rodopoulou S, Cesaroni G, Stafoggia M et al.

Long-term exposure to air pollution and chronic kidney disease-associated mortality-Results from the pooled cohort of the European multicentre ELAPSE-study Environ Res. 2024 Jul 1;252(Pt 3):118942. doi: 10.1016/j.envres.2024.118942. Epub 2024 Apr 20. PMID: 38649012.

Binazzi A, di Marzio D, Mensi C, Consonni D, Miligi L, Piro S, Zajacovà J, Sorasio D, Galli P, Camagni A, Cozzi I et al.

Gender Differences in Sinonasal Cancer Incidence: Data from the Italian Registry.  Cancers. 2024; 16(11):2053. https://doi.org/10.3390/cancers16112053

Nobile F, Dimakopoulou K,  Åström C, Coloma F, Dadvand P, de Bont J et al.

External exposome and all-cause mortality in European cohorts: the EXPANSE project  Front. Epidemiol., 28 May 2024 Sec. Occupational and Environmental Epidemiology Volume 4 - 2024 | https://doi.org/10.3389/fepid.2024.1327218

Conti S, Fornari C, Ferrara P, Antonazzo IC, Madotto F, Traini E, Michelozzi P, Stafoggia M et al.

Corrigendum: Time-Trends in Air Pollution Impact on Health in Italy, 1990-2019: An Analysis from the Global Burden of Disease Study 2019. Int J Public Health. 2024 May 16;69:1607320. doi: 10.3389/ijph.2024.1607320. Erratum for: Int J Public Health. 2023 Jun 02;68:1605959. PMID: 38818229; PMCID: PMC11137273.

Renzi M, Vecchi S, Michelozzi P. 

Climate crisis and Saharan dust advections in Italy: a relevant issue on the public health agenda [Crisi climatica e avvezioni sahariane in Italia: un tema rilevante nell'agenda della sanità pubblica]. Epidemiol Prev. 2024 Mar-Apr;48(2):113-115. Italian. doi: 10.19191/EP24.2.038. PMID: 38775073.

Bisceglia L, Ancona C, Bisanti L, Candela S, Listorti E, Mataloni F, Richiardi L, Traversa G, Clementi ML, Forastiere F.

Priorità e strumenti per valutare l’efficacia degli interventi del SSN: il punto sul dibattito in corso [Priorities and tools to evaluate the effectiveness of Italian National Health Service interventions: spotlight on the current debate]. Epidemiol Prev. 2024 Mar-Apr;48(2):102-106. Italian. doi: 10.19191/EP24.2.034. PMID: 38770725.

Corrao G, Rea F, Iommi M, Lallo A, Fantaci G, Di Martino M, Davoli M, Leoni O, Pompili M, Scondotto S, De Luca G, Carle F, Lorusso S, Giordani C, Di Lenarda A, Maggioni AP; Monitoring and Assessing care Pathways (MAP)' working group of the Italian Ministry of Health.

Cost-effectiveness of outpatient adherence to recommendations for monitoring of patients hospitalized for heart failure. ESC Heart Fail. 2024 May 9. doi: 10.1002/ehf2.14779. Epub ahead of print. PMID: 38725148.

Wen B, Wu Y, Guo Y, Gasparrini A, Tong S, Overcenco A, Urban A, de Donato F, Michelozzi M et al.

Comparison for the effects of different components of temperature variability on mortality: A multi-country time-series study  Environ Int. 2024 May 3;187:108712. doi: 10.1016/j.envint.2024.108712. Epub ahead of print. PMID: 38714028.

Kadelbach P, Weinmayr G, Chen J, Jaensch A, Rodopoulou S, Strak M, de Hoogh K, Andersen ZJ, Bellander T, Brandt J, Cesaroni G, Stafoggia M et al.

 Long-term exposure to air pollution and chronic kidney disease-associated mortality-Results from the pooled cohort of the European multicentre ELAPSE-study. Environ Res. 2024 Apr 20;252(Pt 3):118942. doi: 10.1016/j.envres.2024.118942. Online ahead of print.

Ma Y, Nobile F, Marb A, Dubrow R, Kinney PL, Peters A, Stafoggia M, Breitner S, Chen K.

Air pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries.  Environ Int. 2024 Apr 16;187:108668. doi: 10.1016/j.envint.2024.108668. Epub ahead of print. PMID: 38640613.

Kirchmayer U, Marino C, Feriozzi S, Massimetti C, Manzuoli M, Angelici L, Bargagli AM, Cascini S, Addis A, Davoli M, Agabiti N.

Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016-2020. BMC Nephrol. 2024 Mar 16;25(1):98. doi: 10.1186/s12882-024-03539-5. PMID: 38493085; PMCID: PMC10943891.

da Silva Machado FL, Cañás M, Urtasun MA, Marín GH, Albuquerque FC, Pont L, Convertino I, Bonaso M, Tuccori M, Kirchmayer U, Lopes LC

A Cross-National Comparison of Biosimilars Pricing in Argentina, Australia, Brazil, and Italy. Ther Innov Regul Sci. 2024 Mar 4. doi: 10.1007/s43441-024-00623-8. Epub ahead of print. PMID: 38436905.

Servadio M, Finocchietti M, Vassallo C, Cipelli R, Heiman F, Di Lucchio G, Oresta B, Addis A, Belleudi V.

An epidemiological investigation of high-risk infants for Respiratory Syncytial Virus infections: a retrospective cohort study. Ital J Pediatr. 2024 Mar 25;50(1):56. doi: 10.1186/s13052-024-01627-8. PMID: 38528568; PMCID: PMC10962102.

Nagel G, Chen J, Jaensch A, Skodda L, Rodopoulou S, Strak M, Stafoggia M et al.

Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project Int J Cancer. 2024 Jun 1;154(11):1900-1910. doi: 10.1002/ijc.34864. Epub 2024 Feb 10. PMID: 38339851.

Taj T, Chen J, Rodopoulou S, Strak M, de Hoogh K, Poulsen AH, Stafoggia M et al.

Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort.   Environ Pollut. 2024 Feb 15;343:123097. doi: 10.1016/j.envpol.2023.123097. Epub 2023 Dec 6. PMID: 38065336.

Domingo NGG, Fiore AM, Lamarque JF, Kinney PL, Jiang L, Gasparrini A, Stafoggi M et al.

Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement. One Earth. 2024 Feb 16;7(2):325-335. doi: 10.1016/j.oneear.2024.01.001. PMID: 38420618; PMCID: PMC7615682.

Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney PL, Chen K.

Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries.  JAMA Netw Open. 2024 Mar 4;7(3):e2354607. doi: 10.1001/jamanetworkopen.2023.54607. PMID: 38427355; PMCID: PMC10907920.

Pedersen M, Nobile F, Stayner LT, de Hoogh K, Brandt J, Stafoggia M. 

Ambient air pollution and hypertensive disorders of pregnancy in Rome.   Environ Res. 2024 Mar 5;251(Pt 1):118630. doi: 10.1016/j.envres.2024.118630. Epub ahead of print. PMID: 38452913.

Kirchmayer U, Marino C, Feriozzi S, Massimetti C, Manzuoli M, Angelici L, Bargagli AM, Cascini S, Addis A, Davoli M, Agabiti N. 

Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016-2020. BMC Nephrol. 2024 Mar 16;25(1):98. doi: 10.1186/s12882-024-03539-5. PMID: 38493085; PMCID: PMC10943891.

Barone-Adesi F, Kirchmayer U, Poluzzi E.

La relazione tra farmaci, ambiente e salute è sfaccettata: è arrivato il momento per l’epidemiologia italiana di occuparsene. E&P 2024, 48 (1) gennaio-febbraio, p. 89-90 DOI: https://doi.org/10.19191/EP24.1.A692.026

de Belvis AG, Acampora A, D’Agostino M, Angioletti C, Colais P, Agabiti N, Davoli M.

Come l’audit&feedback potrebbe colmare il divario tra evidenze scientifiche e pratica clinica: riflessioni dal programma di rete EASY-NET. E&P 2024, 48 (1) gennaio-febbraio, p. 85-88 DOI: https://doi.org/10.19191/EP24.1.A669.025

Chen K, de Schrijver E, Sivaraj S, Sera F, Scovronick N, Jiang L et al.

Impact of population aging on future temperature-related mortality at different global warming levels Nat Commun. 2024 Feb 27;15(1):1796. doi: 10.1038/s41467-024-45901-z. PMID: 38413648; PMCID: PMC10899213.

Weinmayr G, Chen J, Jaensch A, Skodda L, Rodopoulou S, Strak M, Stafoggia M et al.

Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project Sci Total Environ. 2024 Feb 20;912:168789. doi: 10.1016/j.scitotenv.2023.168789. Epub 2023 Nov 22. PMID: 37996018.
Gonzalez-Lorenzo M, Ridley B, Minozzi S, Del Giovane C, Peryer G, Piggott T et al. Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis  Cochrane Database Syst Rev. 2024 Jan 4;1(1):CD011381. doi: 10.1002/14651858.CD011381.pub3. PMID: 38174776; PMCID: PMC10765473.
Maritano S, Moirano G, Isaevska E, Pizzi C, Ponzo V, Moccia C, Maule M, Lastrucci V, Alderotti G, Ronfani L, Brumatti LV, Rusconi F, Gagliardi L, Brescianini S, Nisticò L, De Sario M, Culasso M, Richiardi L. Examining the relationship between the environmental impact of diet and child growth from a co-benefit perspective Environ Res. 2024 Feb 14:118496. doi: 10.1016/j.envres.2024.118496. Epub ahead of print. PMID: 38365051.
Minozzi S, Saulle R, Amato L, Traccis F, Agabio R. Psychosocial interventions for stimulant use disorder Cochrane Database Syst Rev. 2024 Feb 15;2(2):CD011866. doi: 10.1002/14651858.CD011866.pub3. PMID: 38357958; PMCID: PMC10867898.
de Bont J, Nori-Sarma A, Stafoggia M, Banerjee T, Ingole V, Jaganathan S et al. Impact of heatwaves on all-cause mortality in India: A comprehensive multi-city study  Environ Int. 2024 Jan 26;184:108461. doi: 10.1016/j.envint.2024.108461. Epub ahead of print. PMID: 38340402.
Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Guo Y, Li S; MCC Collaborative Research Network et al. Global, regional, and national burden of mortality associated with cold spells during 2000-19: a three-stage modelling study  Lancet Planet Health. 2024 Feb;8(2):e108-e116. doi: 10.1016/S2542-5196(23)00277-2. PMID: 38331527.
Madaniyazi L, Armstrong B, Tobias A, Mistry MN, Bell ML, Urban A et al. Seasonality of mortality under climate change: a multicountry projection study Lancet Planet Health. 2024 Feb;8(2):e86-e94. doi: 10.1016/S2542-5196(23)00269-3. PMID: 38331534.
Zafeiratou S, Samoli E, Analitis A, Dimakopoulou K, Giannakopoulos C, Varotsos KV, Schneider A, Stafoggia M, Aunan K, Katsouyanni K.  Modification of heat-related effects on mortality by air pollution concentration, at small-area level, in the Attica prefecture, Greece.  Environ Health. 2024 Jan 24;23(1):10. doi: 10.1186/s12940-024-01053-7. PMID: 38267931; PMCID: PMC10809516.
Rosati P, Crocoli A, Saulle R, Amato L, Brancaccio M, Mitrova Z, Ciliento G, Ciofi Degli Atti M, Raponi M. Does letting adolescent and young adult inpatients share decisions in choosing the central-line insertion site reduce central-line-associated bloodstream infections? An empty systematic review.  J Vasc Access. 2024 Jan;25(1):51-59. doi: 10.1177/11297298221074448. Epub 2022 Feb 3. PMID: 35114837.
Morciano C, Spila Alegiani S, Menniti Ippolito F, Belleudi V, Trifirò G, Zanoni G, Puccini A, Sapigni E, Mores N, Leoni O, Monaco G, Clagnan E, Zappetti C, Bovo E, Cutillo M, Da Cas R, Massari M. Post-marketing active surveillance of Guillain Barré Syndrome following COVID-19 vaccination in persons aged ≥12 years in Italy: A multi-database self-controlled case series study.  PLoS One. 2024 Jan 19;19(1):e0290879. doi: 10.1371/journal.pone.0290879. PMID: 38241309; PMCID: PMC10798452.
Ingrasciotta Y, Spini A, L'Abbate L, Fiore ES, Carollo M, Ientile V, Isgrò V, Cavazzana A, Biasi V, Rossi P, Ejlli L, Belleudi V, Poggi F et al. Comparing clinical trial population representativeness to real-world users of 17 biologics approved for immune-mediated inflammatory diseases: An external validity analysis of 66,639 biologic users from the Italian VALORE project.  Pharmacol Res. 2024 Jan 15;200:107074. doi: 10.1016/j.phrs.2024.107074. Epub ahead of print. PMID: 38232909.
Lio A, D'Ovidio M, Chirichilli I, Saitto G, Nicolò F, Russo M, Irace F, Ranocchi F, Davoli M, Musumeci F. Extended septal myectomy for obstructive hypertrophic cardiomyopathy and its impact on mitral valve function.  J Cardiovasc Med (Hagerstown). 2024 Jan 16. doi: 10.2459/JCM.0000000000001588. Epub ahead of print. PMID: 38251434.
Dimakopoulou K, Nobile F, de Bont J, Wolf K, Vienneau D, Stafoggia M et al. Disentangling associations between multiple environmental exposures and all-cause mortality: an analysis of European administrative and traditional cohorts  Front. Epidemiol., 12 January 2024
Sec. Occupational and Environmental Epidemiology Volume 3 - 2023. doi.org/10.3389/fepid.2023.1328188 
Basile M, Valentini I, Attanasio R, Cozzi R, Persichetti A, Samperi I, Scoppola A, Auriemma RS, Menis ED, Esposito F, Ferrante E, Iatì G, Mazzatenta D, Maurizio Poggi, Rudà R, Tortora F, Cruciani F, Mitrova Z, Saulle R, Vecchi S et al. A pharmacoeconomic analysis from Italian guidelines for the management of prolactinomas Grhta [Internet]. 2024 Jan. 9 [cited 2024 Jan. 15];11(1):1-16. Available from:
Finocchietti M, Marino ML, Rosa AC, Bellini A, Masiero L, Cardillo M, Massari M, Spila Alegiani S, Pierobon S, Ferroni E, Zanforlini M, Leoni O, Ledda S, Garau D, Davoli M, Addis A, Belleudi V Immunosuppression with Generics in Liver and Kidney Transplantation: A Real-World Evidence Study Drug Des Devel Ther. 2024;18:53-69
Squillacioti G, Bellisario V, Ghelli F, Marcon A, Marchetti P, Corsico AG, Pirina P, Maio S, Stafoggia M, Verlato G, Bono R. Air pollution and oxidative stress in adults suffering from airway diseases. Insights from the Gene Environment Interactions in Respiratory Diseases (GEIRD) multi-case control study. Sci Total Environ. 2024 Jan 20;909:168601. doi: 10.1016/j.scitotenv.2023.168601. Epub 2023 Nov 17. PMID: 37977381.
Bellini A, Finocchietti M, Rosa AC, Nordio M, Ferroni E, Massari M, Spila Alegiani S, Masiero L, Bedeschi G, Cardillo M, Lucenteforte E, Piccolo G, Leoni O, Pierobon S, Ledda S, Garau D, Davoli M, Addis A, Belleudi V; CESIT study group Effectiveness and safety of immunosuppressive regimens used as maintenance therapy in kidney transplantation: The CESIT study  PLoS One. 2024 Jan 2;19(1):e0295205. doi: 10.1371/journal.pone.0295205. PMID: 38165971; PMCID: PMC10760756.

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